Gauging heterogeneity in primary versus recurrent glioblastoma
نویسندگان
چکیده
منابع مشابه
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.
Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes, and epigenetic states, but current models do not adequately reflect tumor composition in patients. We used single-cell RNA sequencing (RNA-seq) to profile 430 cells from five primary glioblastomas, which we found to be inherently variable in their expression of diverse transcriptional programs related to...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2015
ISSN: 1523-5866,1522-8517
DOI: 10.1093/neuonc/nov078